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Manish Datt, Ph.D.

Photo of Dr. Manish Datt

Education

Ph.D. Bioinformatics, Institute of Microbial Technology, India
M.Sc. Biotechnology, Panjab University, India
B.Sc. Biochemistry, University of Delhi, India

Select Courses Taught

Data Science

Research

Bioinformatics Molecular Modeling Computational Drug Discovery

Biography

Dr Manish Datt joins Olin as an Argosy Visiting Assistant Professor for Spring semester 2017. He is Assistant Professor at School of Arts and Sciences at Ahmedabad University in Ahmedabad, India. Prior to joining Ahmedabad University, Dr Datt worked as Research Scientist at International Center for Genetic Engineering and Biotechnology, India and at Center for Proteomics and Bioinformatics at Case Western Reserve University, Cleveland, OH. 

Dr Datt’s research is focused on the application and development of computational tools for translational therapeutic research. One of the thrust areas of the lab is to understand structure and dynamics of proteins using structural bioinformatics and computational biophysics methods. Development of tools for annotation of disease-associated mutations in human genome is also being pursued in his lab. 

Dr Datt is actively involved in development and implementation of Ahmedabad University's proprietary pedagogy ENABLE (Engagement and Application Based Learning and Education). He design course that facilitates students to learn basic science irrespective of their academic backgrounds.


Select Publications

Datt M, Sharma A. Conformational landscapes for KMSKS loop in tyrosyl-tRNA synthetases. J Struct Funct Genomics. 2014 Jun;15(2):45-61. 

Datt M, Sharma A. Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus
neoformans. BMC Genomics. 2014 Dec 5;15:1069. 
Kiselar JG, Datt M, Chance MR, Weiss MA. Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling. J Biol Chem. 2011 Dec 23;286(51):43710-6. 
Kanwal R, Datt M, Liu X, Gupta S. Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. PLoS One. 2016 Sep 22;11(9):e0162956.
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